LyoHep‑BloodGas™

LyoHep‑BloodGas™

Glass or plastic — each engineered for optimal blood gas sampling. Lyophilized heparin ensures reliable anticoagulation and true ion balance. Fast wicking, safe handling, and consistent results.

Capillary Blood Gas – When Arterial Access Is Difficult


In the neonatal intensive care unit (NICU) and pediatric wards, arterial puncture is often challenging — arteries are tiny, blood pressure is low, and repeated sampling quickly reduces total blood volume. Capillary blood gas (CBG) sampling offers a less invasive alternative, particularly for stable infants who do not require tight PaO₂ monitoring.
 
The AARC Clinical Practice Guidelines (2022) state that in the absence of an indwelling arterial catheter, capillary blood gas sampling may be used to evaluate acid‑base and ventilation status in neonatal and pediatric patients with cardiorespiratory conditions.

Key limitation: Capillary blood is a mixture of arterial, venous, and interstitial fluid. To obtain results that approximate arterial blood, the site must be “arterialized” — warmed to increase blood flow and dilate capillaries.

 

Preanalytical Risks & Clotting


Capillary blood gas sampling increases the risk of preanalytical errors compared to venous or arterial draws, especially in small infants. Clotting is a frequent cause of sample rejection — in one large NICU study, clotted samples occurred in 3.8% of all blood draws and were most often associated with needle or IV cannula use.

 

Neonatal blood has higher hemoglobin (18–19 g/dL) and unstable coagulation factors, making rapid anticoagulation essential. LyoHep-BloodGas™ tubes contain lyophilized heparin that dissolves instantly upon blood contact, minimizing clot risk without requiring manual mixing.

Arterialization – Making Capillary Blood Reflect Arterial Values


“Arterialization” is the process of warming the puncture site to induce vasodilation and increase blood flow. It transforms capillary blood into a sample that closely approximates arterial blood for pH and pCO₂.

  • Heel warming: Warm the heel with a moist towel or chemical warmer at 40–45 °C for 5–10 minutes before puncture.
  • Earlobe method: In older children and adults, the warmed earlobe provides the best correlation with arterial pO₂.
  • Fingertip: Not recommended for pO₂ assessment — poor agreement with arterial values.

 

Meta‑analysis (Zavorsky et al., 2007): Arterialized capillary blood from earlobe accurately reflects arterial pH and pCO₂ across wide clinical ranges (pH 6.77–7.74, pCO₂ 10–114 mmHg). Earlobe capillary pO₂ may be acceptable when precision is not required; fingertip is not reliable for pO₂.

  Proper warming and technique yield pH and pCO₂ values that correlate well with arterial blood. However, pO₂ from capillary samples should be interpreted with caution.

LyoHep‑BloodGas™ Glass

Superior wettability · Fire‑polished ends

 

 

Glass naturally provides excellent hydrophilicity, enabling fast and complete filling without hesitation. Each glass capillary is fire‑polished at both ends – a high‑temperature treatment that melts microscopic irregularities, creating an edge as smooth as jade. This eliminates the risk of fingertip lacerations and reduces tube breakage during sealing.

  • ✔ Fire‑polished, chip‑free ends
  • ✔ Optimal surface for rapid wicking
  • ✔ Low oxygen permeability → preserves anaerobic conditions
  • ✔ Preferred for research & reference methods

LyoHep‑BloodGas™ Plastic (PET)

Hydrophilic coating · Break‑resistant

 

 

Plastic capillary tubes eliminate shattering risk, but untreated PET is hydrophobic – blood does not flow smoothly. MeterOmega applies a proprietary hydrophilic surface treatment that transforms the inner wall into a low‑contact‑angle, fast‑wicking surface. The result: glass‑like filling speed without the fragility.

  • ✔ Hydrophilic coating ensures rapid, complete fill
  • ✔ No breakage or sharp fragments – safer for busy NICUs
  • ✔ Flexible and lightweight
  • ✔ Ideal for point‑of‑care and prehospital use

LyoHep‑BloodGas™ Capillary Tube – Non‑Sterile

 

REF Material Volume (μL) Diameter (mm) Length (mm) Units per Bottle
178200 PET 165 1.95 125 250
178210 PET 135 1.95 100 250
178230 PET 120 1.95 86.5 250
178650 Glass 165 2.0 100 250
178670 Glass 140 2.0 86.5 250
178690 Glass 120 2.0 73.5 250

 

 

LyoHep‑BloodGas™ Capillary Tube – Sterile (individually pouched)

 

REF Material Volume (μL) Diameter (mm) Length (mm) Units per Pouch
174200 PET 165 1.95 125 1
174210 PET 135 1.95 100 1
174230 PET 120 1.95 86.5 1
174650 Glass 165 2.0 100 1
174670 Glass 140 2.0 86.5 1
174690 Glass 120 2.0 73.5 1

 

Customization & Bulk Orders: Available in alternative lengths, volumes, and private labeling. Non‑sterile bulk bottles or sterile individual pouches. For custom configurations, contact our OEM/ODM team at info@metermega.com.

 References & Further Reading

  • Evans DL, Volsko TA, Capellari E, Strickland SL. AARC Clinical Practice Guidelines: Capillary Blood Gas Sampling for Neonatal and Pediatric Patients. Respir Care. 2022;67(9):1190-1204. PMID: 36002161.
  • Zavorsky GS, Cao J, Mayo NE, et al. Arterial versus capillary blood gases: a meta‑analysis. Respir Physiol Neurobiol. 2007;155(3):268-279. PMID: 17324626.
  • Folk LA. Guide to capillary heelstick blood sampling in infants. Adv Neonatal Care. 2007;7(4):171-178. PMID: 17700114.
  • CLSI GP42‑A6: Procedures and Devices for the Collection of Diagnostic Capillary Blood Specimens, 6th Edition.
  • IFCC “A primer of Point of Care Blood Gas Testing for laboratorians”, 2018.
  • CLSI C46‑A2, Blood Gas and pH Analysis and Related Measurements; Approved Guideline—Second Edition.

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